I admit I've never seen White Chicks or Dumb and Dumber, but I have seen the Nutty Professor movies (the Eddie Murphy versions). I will admit I loved the dinner table scene where Cleatus was doing "the colon cleansing" until he did, well you know what eventually did.
I guess what I'm saying is that it has to be appropriate for the moment. I think some tv shows use it instead of original material and they do it without anytiming or anything else that makes it appropriate.