By far the hardest, most frustratingly ball busting game I have ever experienced is Ninja Gaiden, the newer version, not the old NES title.

I broke 2 Xbox controllers out of sheer frustration trying to get through that game on the default difficulty setting.

I also found the GTA games to be tough if you play them without using any of the cheats, but a lot of that is due to the fact that if you die in the midst of a mission you have to start it all over again.

From the old school games, I remember Gumshoe being REALLY hard. That was an NES game that you played using the Zapper light gun.

Whoever said GRAW I have to agree with as well, if anyone wants a used copy of ti cheap let me know!